![]() ![]() ![]() However, in an ever-changing world, new challenges will be encountered within the next decades. Technological progress in agriculture and plant breeding has contributed significantly to a stable food supply and formed the basis for high yields as well as the production of high-quality agricultural products. Therefore, an in-depth assessment regarding their weight of evidence is mandatory. Studies investigating off-target effects are very heterogeneous in their structure and design. The rapid adoption in plant breeding was demonstrated by a considerable number of market oriented applications (crops and traits) described in publications worldwide. No off-target effects that could be correlated to the genome-editing process were identified in these studies. Only a few studies conducted off-target analyses using unbiased detection methods (e.g. In around 3% of the analyzed potential off-target sites, unintended mutations were detected. Several studies firstly investigated whether sites in the genome show similarity to the target sequence and secondly analyzed these potential off-target sites by sequencing. Most of the studies were conducted using CRISPR/Cas. ![]() Although most of the studies were basic research, 99 different market-oriented applications were identified in 28 different crops leading to plants with improved food and feed quality, agronomic value like growth characteristics or increased yield, tolerance to biotic and abiotic stress, herbicide tolerance or industrial benefits. Genome-editing was already applied in 68 different plants. Most of the studies were conducted in China followed by the USA. ResultsĪltogether, 555 relevant articles from journals, company web pages and web pages of governmental agencies were identified containing 1328 studies/applications of genome-editing in model plants and agricultural crops in the period January 1996 to May 2018. Besides a descriptive summary of the relevant literature, a spreadsheet containing all extracted data is provided. The relevant information of included studies were mapped using a pre-defined data extraction strategy. Articles were screened on title/abstract and full text level for relevance based on pre-defined inclusion criteria. MethodsĪ literature search in nine bibliographic databases, Google Scholar, and 47 web pages of companies and governmental agencies was conducted using predefined and tested search strings in English language. To address these aspects, this map aims to answer the following question: What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects? This primary question will be considered by two secondary questions: One aims to overview the market-oriented traits being modified by genome-editing in plants and the other explores the occurrence of off-target effects. Although the application of genome-editing induces less unintended modifications (off-targets) in the genome compared to classical mutagenesis techniques, off-target effects are a prominent point of criticism as they are supposed to cause unintended effects, e.g. Such techniques provide options for simple, time-saving and cost-effective applications compared to other breeding techniques and hence genome editing has already been promoted for a wide range of plant species. Within the last decades, genome-editing techniques such as CRISPR/Cas, TALENs, Zinc-Finger Nucleases, Meganucleases, Oligonucleotide-Directed Mutagenesis and base editing have been developed enabling a precise modification of DNA sequences.
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![]() In visiting a place we imprint upon it, and it leaves its mark on us as well. A place may be static in its location, but it ages and changes the same as we do, and it carries different weight for each person who arrives there. This paper outlines one of several sense making models developed by the author based on fieldwork across a range of organizations, distinguished between mechanical, Newtonian models of management science and the emerging organic approach, which draws on concepts from complexity theory. The images are a reminder of how much a space can change depending on who is experiencing it. When people are present, they often feel dreamlike, fixed to that particular setting. In many of them, the absence of people is pronounced. Some of these photographs were taken over the past year under these circumstances, while others are from the past, reconsidered in the light of our new reality. Sharing space with another person is selective, if not precious. For many of us, meandering walks and drives are our solace. ![]() Our homes are now multiuse-not only the sites of work, learning, and leisure but as the one place we may feel truly safe. Some spaces are inaccessible to us, while others are deeply intimate. Though photography has always been a means of travel, its utility has a new significance when each of our worlds has narrowed due to the pandemic. "A Sense of Place" called upon photographers to consider the choices they make to communicate a scene at a time when our relationship to places has radically changed. Other times our memories of a setting are centered around a person-or that person's absence. A location may only stay with us for a particular feeling it evoked, while its physicality remains murky. Sometimes it's an innocuous detail that burrows itself into our brains-light scattered on a tablecloth, or clutter strewn on a desk. See what impact it has on your photos you might be impressed by the results.What are the elements that make up a place and ingrain it in our memories? Place is more than a stretch of land or the space between two walls. After all, you can always crop your photos later on! (Just make sure to keep the gridlines in mind when editing.)īy the way, if you want to start practicing the rule of thirds immediately, you can always pull up old photos and do some test cropping. That way, you can determine your points of interest, then you can immediately place them along a rule of thirds gridline or power point.Īnd your composition ends up beautifully balanced.Īlso, if you fail to use the rule of thirds in a shot, it’s not the end of the world.
![]() Privacy Statement: Terms of Use: maxx <33 See the Netflix Privacy Statement (link below) to learn more about information we collect in other contexts, including account registration. Please note that the App Privacy information applies to information collected through the Netflix iOS, iPadOS and tvOS apps. There are no long-term contracts or cancellation fees. You can easily cancel at any time, online, 24 hours a day. Netflix membership is a month-to-month subscription that begins at sign up. Preview quick videos of our series and movies and get notifications for new episodes and releases.Enjoy a safe watching experience just for kids with family-friendly entertainment.The more you watch, the better Netflix gets at recommending TV shows and movies you’ll love.Browse new titles or search for your favourites, and stream videos right on your device. We add TV shows and movies all the time.And with the mobile app, you get Netflix while you travel, commute or just take a break. We’ve got award-winning series, movies, documentaries and stand-up specials. Speaking of which, if you’re interested in iOS video games, TechRadar has a massive list of the best ones for 2022.Looking for the most talked about TV shows and movies from around the world? They’re all on Netflix. We then asked why video games aren't included in the definition, but we haven't heard back yet. All we got in return are links to the reader app definition (opens in new tab). We asked Apple if there are plans to extend the external link support to video games so developers can avoid the fee. The court decision arguably paved the way for the March 2022 policy change, but games are still not included in the reader app definition. The judge in the case ruled against Apple, seemingly allowing developers (opens in new tab)to implement their own third-party payment systems to avoid the fee. He complained that since Netflix can now avoid “Apple's 30 App Tax,” why can’t video games? Epic Games sued Apple over the 30 percent cut back in 2020. This omission was pointed out by Epic Games founder and CEO Tim Sweeney on Twitter (opens in new tab). Magazines, newspapers, books, audio, music, and video apps fall under this umbrella, but not video games. Analysis: what about video games?Īpple’s App Store guidelines define a reader app (opens in new tab) as one that provides a certain type of digital content as its main function. Similarly, South Korea enacted a law in 2021 that allows developers to bypass Apple's fee.Īt a glance, it appears Apple made the reader app change to avoid future headaches, but there is one major omission. ![]() There's a new Dutch law, for instance, that demands non-iOS payment options for people using dating apps in the Netherlands. ![]() Apple's new attitude is driven, in part, by pressure to change. In March 2022 (opens in new tab), Apple announced a policy adjustment that would allow "reader" apps to provide links to their own subscription pages. What was once a hard-fast rule, though, has started to loosen. This wasn’t the most arduous task, but it added unnecessary extra steps. Users had to first purchase a Netflix subscription separately and then download the Netflix app in order to stream. Not ognly that, Apple wouldn’t allow developers to add an external link to their website to avoid that hefty fee. Netflix used to allow people to directly sign up for its service via the iOS app but removed that option because of Apple’s policy of taking a 30 percent cut from all in-app purchases. ![]() Some optimizations reduce the image’s quality – that is called a “lossy” compression, and some leave the quality intact, and that is called a lossless compression. Added ability to set maximum height (thanks Update to read me, no feature updates unfortunately.We often hear the phrase Image Optimization in the context of site building and maintenance, but what exactly does it mean? Image optimization is the compression of an image’s file size (its weight) without changing its dimensions (its width and height).Increased the default maximum height and width to 1200px each.Updated the screenshot to include new maximum height field. ![]() Adds default option for max-height value.Corrected functionality that sets default plugin options if the plugin version number changes.the image is actually larger than the max height/width. Now only runs images through the resizer if required, i.e.Added ability to set the JPEG compression quality level when JPEGs are resized.Code was deployed prematurely and should not have made its way to the live repository.Reverting code back to how it was in v1.3.0 after previous premature deployment of v1.4.0.Added ability to enter a resize value of zero (0) to prevent resizing in a particular dimension.Compression quality value was not adhered to.Ability to force re-compression even if resize is not required.Replaced use of deprecated PHP functions with correct ones.Media upload was failing for BMP images.Resizing wasn’t running on square images.Significant number of bug fixes through extensive testing.This is a major maintenance release to squash a few long outstanding bugs. Correct the logic behind which direction to perform resizing in.Correcting an error in the documentation.įix a few edge case bugs, I go and break the main functionality – that’s life! This is a maintenance release to fix a bug.Plugin completely re-engineered to use WP_Image_Editor when resizing images.This should improve the output of your resized images! ImageMagick), then the resizing method should make use of them. This means that should your server have better image processing libraries than the GD default (e.g. The plugin still functions as normal, but the way in which it resizes images has now changed to use standard WordPress libraries. This is a major under-the-hood release to change core workings of the plugin. After reports of the plugin resizing PDF files, added check to ensure the plugin only attempts a resize on JPEG, GIF, and PNG file types other than relying on the response from WP_Image_Editor.Undefined option notices when running WordPress in debug mode.Better sanitize post data when saving settings.Skip animated GIFs that GD can’t resize.Improve security to the settings form by using nonce.WP SVG Images – Secure upload of SVG files to Media Library.reGenerate Thumbnails Advanced – Easily regenerate thumbnails.Enable Media Replace – Easily replace images or files in Media Library.ShortPixel Adaptive Images – On-the-fly image optimization & CDN delivery.ShortPixel Image Optimizer – Image optimization & compression for all the images on your website, including WebP & AVIF delivery.Is that simple, just give it a try, it is safe and free! □ In addition, the plugin can force the re-compression of uploaded JPEG images and convert PNGs to JPEG (if they don’t have a transparency layer), regardless of whether they are resized or not. Imagine that nowadays images can be over 4-5MB and using this plugin you can reduce them to 100-200KB with no extra effort on your side! This plugin automatically resizes images (JPEG, GIF, and PNG) when they are uploaded to within a given maximum width and/or height to reduce server space usage, speed up your website, save you time and boost your site’s SEO. Supported by the friendly team that created ShortPixel □ A free, fast, easy to use, stable and frequently updated plugin to resize your images after upload. ![]() ![]() View agent, publicist, legal and company contact details on IMDbPro. Other Works Publicity Listings Official Sites. Connecting businesses to the Hispanic community, showcasing products and strengthening brands, La Feria de La Familia® is an interactive expo of exceptional quality, guaranteed to inform, empower and entertain. Raengel Solis is known for Nuestra Belleza Latina (2006). Over the years, La Feria de La Familia® has established itself as a dynamic and powerful forum. Who Is Raengel Solis (Gregory Soto Wife) Career And Married Life Details Explored Mansi JanuPlayers Wife And Girlfriend Gregory Soto Gregory Soto is a Dominican professional baseball pitcher that competes on an international level. There will be an area dedicated to children with face painting and performances from their favorite cartoon characters. The event will conclude with a stellar performance by salsa legend, Jose Alberto "El Canario".Īs part of the La Feria de la Familia® festivities, attendees will be able to act as special Telenoticias Tampa weather correspondents for the day with weather presenter Raengel Solis. Entertainment will include games and live performances by megastar of urban music Ken-Y, season four champion of La Voz Kids (The Voice Kids), Christopher Rivera. Also Read:Who Is Raengel Solis (Gregory Soto Wife) Image: Christina Kokkinakis with her co-worker during the interview. Univisions Nuestra Belleza Latina finalist Raengel Solis poses backstage at Greenwich Studios after the final episode on in Miami, Florida. The main stage will be emceed by the hosts of the 92.5 Maxima morning show Cristy and Ñeko. ![]() This year Telemundo Tampa's La Feria de la Familia® will pack star power. They will participate in exciting games and contests and have the unique opportunity to meet their favorite Telemundo personalities alongside Telemundo Tampa's local news team, Telenoticias Tampa. Held annually during Hispanic Heritage Month, La Feria de la Familia® celebrates the community's traditions and culture.Īttendees of La Feria de la Familia® will learn about businesses and services available in the Tampa Bay area. The free expo provides the local Hispanic community with a full day of live entertainment, information, and resources in a fun family atmosphere. Raengel Sols raengelsolis2491 205 subscribers Subscribe Home Videos Shorts Playlists Channels About Videos Play all 2:42 Raengel Solis en: Premios Billboard Alfombra Roja 2017 442 views5. On-Air times vary, regularly on weekends 11pm while the. 21, 2016 - PRLog - The 12th edition of Telemundo Tampa's premier family event, La Feria de la Familia®, presented by Fucillo Kia, will take place on Sunday, October 2 from 11am to 6pm at the Florida State Fairgrounds. Raengel Solis (RECENT) all in 1 human beauty - YouTube Raengel Solis reports on weather forecasts and traffic at TELEMUNDO47 New York. Only one EPP can be equipped at any given time - however, they can modified with an Augment and/or paired with Armor to balance resistances. Ornamental wings handmade from paper and wood. FU : tukimiblog, WikiGetting Started It is strongly recommended that players bring bandages, stim packs and buffed foods with them regardless of their intentions to fight. Just place the Lab Directory somewhere nearby, search for Contaminated Water, then click "As Output". biome ID: fftarpitregion ID: fftarunderground, biome ID: blaststonecorelayerregion ID: core, biome ID: magmarockcorelayerregion ID: core, biome ID: obsidiancorelayerregion ID: core. The high winds blow rocks around that can do some serious hurt to you. these are materials from Frackin universe, to make the nitrogen you simply find a fridgid ocean planet and the water should be liquid nitrogen. Most if not all of these planets have no breathable atmosphere, and require some form of breath protection to not suffocate. as for the dense alloy theres a few things you need, you'll need a biochem lab, and a fission furnace. Item Name Equip these gilded, batlike wings and become the stuff of nightmares! There used to be a bowl item in the game for feeding your ship pet, however they realized barely anyone bothered to feed their pet as it served no purpose other than removing the clouds of sadness. Deadly pools of acid and lethal storms lie below in abundance. It boasts new armors, new weapons, new mechanics, new biomes, new dungeons, new quests, new crew, new mech parts, new vehicles, automation. Additionally, any piece of Armor which includes acid protection will have the same effect and also provide immunity to Sulphuric Acid as long as it is equipped. Sulphuric planets can be found orbiting Binary, Radioactive, Red and Temperate Stars. ![]() Adds poison neutralization to your EPP's capabilities. The added energy and health is nice, too. If you think this page needs a particular piece of information. +7 health, +7 Energy, +7 Shield Bash, +20% damage. It's quite spacious inside! Use it on planets with high poison levels. Great for warm climates such as deserts and rainforests. 3.Smelt it.I know it can take a long time to smelt almost an entire full stack of zerchesium but it brings up the value by quite a bit. 2.Mine lots of zerchesium.With a tier 3 mining laser i was able to get 1700 ore in about 20 minutes.Tip:dont waste your time near surface level,just go a bit deeper until almost every block is an ore. Sulphuric worlds have three primary environmental dangers. Total Heat, Cold, Proto-Poison and Radiation Immunity. FrackinUniverse Wiki is a FANDOM Games Community. ![]() Why would you even consider wearing this on your back? +2% Physical Resistance. You can find some settlements here, but theyre usually Apex or Human and often very unfriendly.You can also find Whitespine here, which provides temporary immunity to the acidic environment. Many of the common types of weather, however, appear to have no countermeasures, making surface exploration dangerous even for the best-equipped adventurers. An ancient cape made from a mysterious glimmering material. Chitin, Reptile, Acid Augment, Bone-Steel, and several other methods exist to shield yourself. Dumping pus into water creates contaminated water. In addition to the deadly environment, Sulphuric worlds contain very powerful, aggressive wildlife. ![]() Unlocked by Advanced Liquids (Chemistry tree). The pools of boiling hot sulphuric acid aren't incredibly healthy either. ![]() My Little Pony: Friendship Is Magic focuses on six core pony characters, identified as the "Mane Six", a group of friends who are brought together by the "Elements of Harmony", a set of six mystical jewels and an "unstoppable force of good" used to defend Equestria against powerful threats. Faust still aimed for the characters to be "relatable" characters, using stereotypical "icons of girliness" to broaden the appeal of the characters for the young female audience. Elements of the characters' personalities and the show's settings were based on her childhood imagination of the ponies' adventures, in part inspired by the animated shows that her brothers would watch while growing up, such as Transformers and G.I. To do this, she incorporated many elements into the show that subverted stereotypes of girls, such as diverse personalities, character flaws and personality disorders, the message that friends can be different and can get into arguments but still be friends and the idea that girls should not be limited by what others say they can or cannot do. With the chance to work on My Little Pony, one of her favorite childhood toys, she hoped to prove that "cartoons for girls don't have to be a puddle of smooshy, cutesy-wootsy, goody-two-shoeness". She was disappointed that what she thought of the toys at the time was nothing like the animated shows, in which the characters, according to her, "had endless tea parties, giggled over nothing and defeated villains by either sharing with them or crying". Faust said she was "extremely skeptical" about taking the job at first because she had always found shows based on girls' toys to be boring and unrelatable. Hasbro initially hired Faust to create a pitch bible for the show, allowing her to get additional help with conceptualization. Friendship is Magic characters appear in numerous spin-off franchise media, including a comic book series, a Gameloft My Little Pony video game, a children's book series, a theatrical movie adaptation and the spin-offs My Little Pony: Equestria Girls, where several Friendship is Magic characters are re-envisioned as humans in a high school setting, and My Little Pony: Pony Life, a reboot focusing on more slice-of-life stories. The characters have been generally well-received by television critics and parental groups and are cited as one of the reasons the series' older fans, called " bronies", became attracted to the show. The series premiered on October 10, 2010, in the United States and concluded on October 12, 2019. The series features characters and settings developed by Lauren Faust, who sought to create more in-depth characters than the stereotypical "girly" icons used in previous iterations of the franchise. This is a list of characters from My Little Pony: Friendship Is Magic, an animated television series based on the My Little Pony toyline created by American toy manufacturer and multimedia company Hasbro. A 2011 Comic-Con poster depicting many characters from the first season. Not much is really needed when the meat is fresh and of high quality anyway. He says that this is the same as the original recipe which was founded all the way back in Medieval Europe. He doesn't put any other ingredients or spices in it. It's just uses pork, fat, salt and pepper. ![]() I think the secret to his recipe is that it's very basic. ![]() I have to say that it is one of the best sausages I have had, almost as good as the Swedish korv sausage I grew up eating. My friend actually makes his own salchichon sausage at home and I had the opportunity to taste it a couple of times. But salchichon is as popular in Italy as it is in Spain apparently. I guess it's possible, I don't think there is any proof either way. But the method of making them and the quality and kind of meat is the same as salchichón.Ī friend of mine is of Italian origin and he claims salchichon sausage originated in Italy. The seasonings I remember being included in these off the top of my head are garlic, cinnamon, paprika, bell peppers and vinegar. I don't think nutmeg is used in chorizo or longaniza. Both of these are pork sausages like salchichón, I think the only variation is the seasonings. Salchichón sausage sounds a lot like two other Spanish sausages, chorizo and longaniza sausage. Pork sausages are popular all over Europe really, whereas beef and lamb sausages are more the norm in Eastern Mediterannean countries and the Middle East. I think sausages made from pig meat is quite popular in Spain. Their cuisines might be similar, but I'm pretty sure that salchichon is a Spanish You're right, those sausages are very similar. I've has salsiccia sausages with fennel seeds but I don't know if all salsiccia sausages are made that way.īoth Spain and Italy are Mediterranean countries and I'm sure the two cultures were influenced by one another. ![]() It's also the Spanish word for "sausage." The Italian version of salchichon is called "salsiccia" as far as I know. What Are the Different Types of Spanish Sausages?Īpril 16, Salchichon is Spanish. ![]() VPN Tracker 365, the leading Mac VPN client, now supports SonicWALL SSL VPN connections for Mac users. 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Amy is the more “hands-on” side of the ownership as Greg is also the Executive Pastor at Owensboro Christian Church. ![]() The coffee and espresso served at Gramps is brewed from Onyx Coffee Lab beans, Gramps’ official roaster.īecause Gramps uses a different type of dough, their donuts take longer to proof and cook than traditional donuts, Greg said. Some of the names are even related to Gramps’ corny jokes and sayings, according to Greg. “We believe having a light and flaky donut gives a different option from the rest of Owensboro.”Īnd the names of the donuts are just as unique, including the Happy Camper, which is topped with a marshmallow glaze Goodness Gracious, which is topped with a chocolate glaze with cookies and cream crumbles and the Sap Tapper, which has an all-the-rage maple glaze. “There were already so many great bakeries in town with delicious traditional donuts, however, so we knew we wanted to celebrate what those businesses were doing while we created something different,” Greg said. With their desire to create something unique with Gramps, the Gilmores are also bringing a different style of donuts to Owensboro. ![]() “He’s had a couple of people come up to him and share their stories of dealing with cancer…The funniest thing for my wife and I, however, is to see him take various ‘selfies’ with people, and we have jokingly said he could run for office soon with the amount of people he is talking with.” He truly loves interacting with each person as they enter the door of Gramps,” Greg said. “It’s been great seeing my dad - who we jokingly call our mascot - being able to care for people as they come and go from the shop. In fact, Gramps, who is in remission, can often be found greeting customers from inside the shop, but recently has been holding the door open for customers as most of the seats inside are taken. Gramps is the name the Gilmore’s youngest son bestowed on Dennis, and they felt this was the perfect name for a community coffee and donut shop. The name of the establishment honors Greg’s dad, Dennis. “We know that the building has seen and heard many stories over the years, and we wanted to keep that sense of history and add to its story with what Gramps is doing,” Greg said. They added a long, high-top table and a seating area in the front for customers to spend time. The Gilmores also exposed some of the original brick and restored the original tin ceiling. “The building is over 100 years old and used to house the Chamber of Commerce, the Red Cross, and other businesses over the years.” ![]() “We want everything we do to be done with a unique twist, so we updated the building to reflect the past, but also add a modern take to the space, as well,” Greg said. The Gilmores searched for the perfect location that would include character and charm, which they believe they found in their location at the corner of 4th and Frederica. During this time, the Gilmores realized that life was short and decided they needed to make Amy’s dream a reality. Two years ago, Greg’s dad Dennis was diagnosed with bone cancer, and he was unable to visit coffee shops, something he would regularly do and where he would tell jokes, share stories, meet and mentor people. ![]() That dream was on hold until a family event pushed it to the forefront. Amy had always wanted to start a bakery where she could not only serve customers but also develop relationships with those who entered. Gramps’ owners Amy and Greg Gilmore returned to Owensboro six years ago after living in Lexington for almost two decades. Gramps Coffee and Donuts is new to the scene in Owensboro, but for the customers who enter, the feeling is not one of entering a new place, but rather visiting an established neighborhood coffee shop. Gramps brings their unique take on donuts to Downtown |